-Update the drivers of your graphic card and check the minimum requirement.
-Wait a little at launch of the game, even if "does not respond" appears, the game may require time to launch on low configurations especially.
-Browse the solutions of the FAQ
If the problem persists try this:
Open Steam and go to Library, right click on the game and go to Properties then in Local Files and finally open the game folder to access Syberia3 (.exe), right click and go to Properties.
Go to Compatibility and check "Disable display scaling for high DPI settings"
Clic OK then launch your game normally.